Velasco et al. Thyroid Hormone Receptor Dimerization 1 THYROID HORMONE RESPONSE ELEMENT ORGANIZATION DICTATES THE COMPOSITION OF ACTIVE RECEPTOR

1 THYROID HORMONE RESPONSE ELEMENT ORGANIZATION DICTATES THE COMPOSITION OF ACTIVE RECEPTOR Lara Franciele Ribeiro Velasco, Marie Togashi, Paul G. Walfish, Rutinéia de Paula Pessanha, Fanny Nascimento Moura, Gustavo Barcelos Barra, Phuong Nguyen, Rachelle Rebong, Chaoshen Yuan, Luiz Alberto Simeoni, Ralff Carvalho Justiniano Ribeiro, John D. Baxter, Paul Webb, Francisco de Assis Rocha Neves From the Molecular Pharmacology Laboratory, Department of Pharmaceutical Sciences, School of Health Sciences, University of Brasilia, Brasília, DF, Brazil. Diabetes Center and Department of Medicine, University of California, San Francisco, CA 94143, USA and Department of Medicine, Endocrine Division, Mount Sinai Hospital, University of Toronto Medical School, Toronto, ON, Canada, M5G 1X5. Running Title: Thyroid Hormone Receptor Dimerization *These authors contributed equally to the work. RCJR Deceased ^Correspondence to: F. A. R. Neves, M.D., Ph.D., Laboratorio de Farmacologia Molecular, Departamento de Ciências Farmacêuticas, Universidade de Brasília, Caixa Postal – 4473, 70919-970 -Brasília -DF Brazil, tel. +55 61 3072098, fax +55 61 3474622, e-mail: [email protected] and to P. Webb Ph.D., Diabetes Center & Department of Medicine, University of California, San Francisco CA94122. USA tel 1-415-476-6789, fax 1-415-564-5813, e-mail [email protected].